Fig. 7: HDACi increases radiosensitivity in vivo. | Cell Death & Disease

Fig. 7: HDACi increases radiosensitivity in vivo.

From: CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Fig. 7

a The overall diagram of the study design. The NPC xenograft model was established using HONE1-EBV cells. b Representative images of xenografts from different treatment groups. Control: saline vehicle; Chidamide: Chidamide 5 mg/kg; IR irradiation with 4 Gy; IR + Chidamide: Chidamide-irradiation combination. c The tumor volume of xenograft from the indicated treatment group (n = 5). d Tumor weight of HONE1-EBV-derived xenografts from the indicated treatment group (n = 5). e–g Tumor sections were stained with hematoxylin and eosin (H&E) and subjected to immunohistochemistry detection for 8-OHdG and γH2AX (scale bar, 500 μm). Results are plotted as the mean surviving fraction ± SEM.

Back to article page