Fig. 3: NK cells exhibit anticancer effects through diverse mechanisms. | Cell Death & Disease

Fig. 3: NK cells exhibit anticancer effects through diverse mechanisms.

From: Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside

Fig. 3

NK cells exhibit broad-spectrum anticancer effects via various mechanisms, including antibody-dependent cell-mediated cytotoxicity (ADCC) via CD16 binding, secretion of cytokines (IFN-γ, TNFα), release of cytolytic granules (e.g., granzyme B), and expression of death ligands. The balance of NK cell activity is regulated by activating and inhibitory receptors.

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