Fig. 2: Contrast media suppresses ER-phagy, exacerbating ER stress and apoptosis.
From: DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis
A Diagrammatic representation of CI-AKI mice (Model + Iohexol, 10 ml/kg), negative control mice (Model + NS), and control mice. The renal function was evaluated by serum creatinine (B) and BUN (C). D Representative histology of HE and PAS staining in the renal cortex. Scale bar: 500 μm and 50 μm. E–I The immunoblot analysis and quantification of DDRGK1, UFL1, UFM1, CANX in kidney lysates. J TEM images of ER in renal tubular epithelial cell. Red arrows: ER. K–M The immunoblot analysis and quantification of GRP78 and CHOP in kidney lysates. N, O The immunoblot analysis and quantification of BAX in kidney lysates. Data are presented as the mean ± SEM (n = 5). **p < 0.01 and ***p < 0.001.
