Fig. 3: IRI inhibits ER-phagy, intensifying ER stress and apoptosis. | Cell Death & Disease

Fig. 3: IRI inhibits ER-phagy, intensifying ER stress and apoptosis.

From: DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis

Fig. 3

A Diagrammatic representation of IRI mice (right nephrectomy and left kidney ischemia 30 min) and sham mice. The renal function was evaluated by serum creatinine (B) and BUN (C). D Representative histology of HE and PAS staining in the renal cortex. Scale bar: 500 μm and 50 μm. E–I The immunoblot analysis and quantification of DDRGK1, UFL1, UFM1, CANX in kidney lysates. J TEM images of ER in renal tubular epithelial cell. Red arrows: ER. K–M The immunoblot analysis and quantification of GRP78 and CHOP in kidney lysates. N, O The immunoblot analysis and quantification of BAX in kidney lysates. Data are presented as the mean ± SEM (n = 5). ***p < 0.001.

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