Fig. 4: MTHFD1 increased NADPH/NADP+ levels and GSH/GSSG levels, reduced ROS levels.
From: MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma
A Levels of NADPH/NADP+ in SK-N-BE(2) and IMR32 cells with or without MTHFD1 knockdown. B Levels of GSH/GSSG in SK-N-BE(2) and IMR32 cells with or without MTHFD1 knockdown. C Levels of intracellular ROS in SK-N-BE(2) cells with or without MTHFD1 knockdown. D Levels of intracellular ROS in IMR32 cells with or without MTHFD1 knockdown. E, F Changes of apoptosis rates in SK-N-BE(2) and IMR32 cells after MTHFD1 genetic knockdown in the presence or absence of NAC. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
