Fig. 5: Knockdown of MTHFD1 enhanced the anti-tumor effect of JQ1 in NB.
From: MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma
A The cell viability of the indicated NB cells treated with JQ1 for 72 h was analyzed using CCK-8 assay. B Proliferation of NB cells with or without MTHFD1 knockdown in the presence of vehicle control (Ctrl) and 0.2 μM JQ1. C, D Changes of apoptosis rates in SK-N-BE(2) and IMR32 cells with or without MTHFD1 knockdown treated with vehicle control or JQ1 for 48 h. E Pictures of subcutaneous xenografts. F Growth curves of subcutaneous xenografts derived from SK-N-BE(2) shNC and shMTHFD1 cells in NCG mice that were administered vehicle control (Ctrl) or 50 mg/kg/d JQ1. G Quantification of tumor mass. **P < 0.01, ***P < 0.001, ****P < 0.0001.
