Fig. 1: ID4 expression correlates with motility-related pathways in breast cancer. | Cell Death & Disease

Fig. 1: ID4 expression correlates with motility-related pathways in breast cancer.

From: ID4-dependent secretion of VEGFA enhances the invasion capability of breast cancer cells and activates YAP/TAZ via integrin β3-VEGFR2 interaction

Fig. 1

A gene sets enrichment analysis showing activated pathways in BC expressing high vs. low levels of ID4. B graphs showing the correlation between ID4 expression and focal adhesion pathway, ID4 expression and ECM receptor interaction pathway, and ID4 expression and CAM KEGG pathway in breast cancer patients. C heatmap derived from TCGA BRCA dataset showing ID4 expression and the activation of CAM pathway, Focal adhesion pathway, and ECM receptor pathway in LUMA, LUMB, HER2, and BASAL BC subtypes. D box blots derived from TCGA BRCA dataset showing ID4 expression levels in the different BC subtypes. E box blots derived from TCGA BRCA dataset showing expression levels of FOXA1, GATA3, BRCA1, KRT18, KRT8, and KRT19 in the LUMA subtypes expressing high vs. low ID4 expression levels.

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