Fig. 6: ID4/VEGFA axis stimulates nuclear YAP localization via integrin β3/VEGFR2 signaling in BC cells.

A immunofluorescence analysis of YAP in M6 Control cells treated with vehicle or Cilengitide at 0.1 µM, with the relative mean fluorescence intensity quantification in nuclei and cytoplasm. B immunofluorescence analysis of M6 ID4-KO cells treated with vehicle, Cilengitide, and/or VEGFA, with the relative mean fluorescence intensity quantification in nuclei and cytoplasm. Scale bar: 50 µm. Data are presented as mean ± SD. **P < 0.01, ****P < 0.0001 calculated by Student’s t test (A) or One-way Anova (B) on n = 3 experiments.