Fig. 7: ID4 correlates with nuclear YAP/TAZ and with YAP/TAZ signatures in BC patients. | Cell Death & Disease

Fig. 7: ID4 correlates with nuclear YAP/TAZ and with YAP/TAZ signatures in BC patients.

From: ID4-dependent secretion of VEGFA enhances the invasion capability of breast cancer cells and activates YAP/TAZ via integrin β3-VEGFR2 interaction

Fig. 7

A heatmap derived from TCGA BRCA dataset showing ID4 expression and the activation of three YAP/TAZ signatures from MsigDB in LUMA, LUMB, HER2 and BASAL breast cancer subtypes. B box plots from TCGA BRCA dataset showing the expression levels of three YAP/TAZ signatures in ID4 high vs ID4 low breast cancers. C graphs derived from TCGA BRCA dataset showing the correlation between three different YAP/TAZ signatures and ID4 expression in breast cancer. D immunohistochemistry staining of ID4, YAP, and TAZ in tissue microarrays of TNBC, and pie charts showing the percentages of cells expressing high or low nuclear YAP/TAZ staining in tissues expressing high or low ID4. Statistical analysis of TMA data was performed by Fisher’s exact test.

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