Fig. 7: ID4 correlates with nuclear YAP/TAZ and with YAP/TAZ signatures in BC patients.

A heatmap derived from TCGA BRCA dataset showing ID4 expression and the activation of three YAP/TAZ signatures from MsigDB in LUMA, LUMB, HER2 and BASAL breast cancer subtypes. B box plots from TCGA BRCA dataset showing the expression levels of three YAP/TAZ signatures in ID4 high vs ID4 low breast cancers. C graphs derived from TCGA BRCA dataset showing the correlation between three different YAP/TAZ signatures and ID4 expression in breast cancer. D immunohistochemistry staining of ID4, YAP, and TAZ in tissue microarrays of TNBC, and pie charts showing the percentages of cells expressing high or low nuclear YAP/TAZ staining in tissues expressing high or low ID4. Statistical analysis of TMA data was performed by Fisher’s exact test.