Fig. 6: CHCHD2-mediated neuronal protection is associated with the activation of Nrf2-ARE signaling. | Cell Death & Disease

Fig. 6: CHCHD2-mediated neuronal protection is associated with the activation of Nrf2-ARE signaling.

From: CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress

Fig. 6

A ARE-luciferase assay was tested by TBHP treatment in SH-SY5Y cells. B KD of CHCHD2 resulted in decreased expression of ARE-Luciferase in Q7 cells. C OE of CHCHD2 induced up-regulated expression of ARE-Luciferase in Q7 cells. n = 3 independent biological replicates for (A–C). D The expression levels of antioxidant target genes (GCLM, HO-1, and NQO1) were increased in Q7 cells with CHCHD2 overexpression. n = 4 independent biological replicates. Values shown as mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 was determined by unpaired student t-test. E Schematic of CHCHD2 up-regulation in HD cells mediating a compensatory protective response against oxidative stress.

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