Fig. 5: GSDME in keratinocytes promotes psoriasis-like skin inflammation. | Cell Death & Disease

Fig. 5: GSDME in keratinocytes promotes psoriasis-like skin inflammation.

From: Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Fig. 5

A Neutrophil infiltration was evaluated by detecting Ly6G and MPO through immunohistochemistry study. Statistical analysis of mean staining intensity was shown. B Quantitative real-time PCR analysis was performed to determine the mRNA levels of Il17a, Il23a, Tnfa, Il1b, Ccl20, Cxcl1, Cxcl2, S100a8, and S100a9. Statistical analysis was shown. C The percentage of CD4+T cells (CD3+CD4+), Th1 cells (CD3+CD4+IFN-γ+), and Th17 cells (CD3+CD4+IL-17A+) in spleen was determined by flow cytometry. Statistical analysis of specific cell percentages was shown. Scale bar represents 100 μm in A. ns not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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