Fig. 3: Loss of caspase-2 alters the expression of genes involved in the regulation of cellular stress pathways. | Cell Death & Disease

Fig. 3: Loss of caspase-2 alters the expression of genes involved in the regulation of cellular stress pathways.

From: Caspase-2 protects against ferroptotic cell death

Fig. 3

Volcano plots illustrating DEGs in a H1299p53R273H cells transfected with CASP2 siRNA vs. control siRNA and b CASP2−/− vs. Cas9 H1299p53R273H cells. Red dots indicate DEGs with nominal P-value < 0.05 and log2FC > or < –1. The top 10 (based on log2FC) upregulated and downregulated DEGs are labeled. c Venn diagram of unique and overlapping DEGs (P-value < 0.05) in CASP2 siRNA vs. control siRNA group and CASP2−/− vs. Cas9 group. d Heat-map displaying common up/downregulated genes with log2FC > 1 or < -1. e GO term analysis of the significantly enriched biological processes (nominal P-value < 0.01) in common DEGs in the absence of caspase-2 using Metascape [8].

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