Fig. 2: Inhibition of IGF2BP3 suppresses GC cell growth and migration in vitro.
From: The RNA m6A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer
A The expressions of IGF2BP3 in MKN-45 and AGS cells infected with two independent shRNAs targeting IGF2BP3 or a control shRNA were measured by western blot analysis (left) and quantitatively analyzed (right), respectively. B Wound healing of shNC and shIGF2BP3 MKN-45 and AGS cells were recorded (up) and quantitatively analyzed (down), respectively. C Migration and invasion of shNC and shIGF2BP3 AGS cells were recorded (left) and quantitatively analyzed (right), respectively. D Colony formation of shNC and shIGF2BP3 MKN-45 and AGS cells were recorded (up) and quantitatively analyzed (down), respectively. E Cell proliferation of shNC and shIGF2BP3 MKN-45 and AGS cells were detected using EdU staining, respectively. F The expressions of Cytochrome c, PARP, Caspase-3 and Cleaved caspase-3 in shNC and shIGF2BP3 MKN-45 cells were measured by western blot analysis.
