Fig. 7: OTUD4 contributes to glioblastoma growth in vivo. | Cell Death & Disease

Fig. 7: OTUD4 contributes to glioblastoma growth in vivo.

From: OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway

Fig. 7

A Representative IHC images with positive correlation between OTUD4 and CDK1 expression in human glioma tissue sample chips. Scale bar, 200 μm. B Spearman correlation test of OTUD4 and CDK1 expression. C, D Prognostic analysis using the CGGA database to explore the clinical correlation of OTUD4 and CDK1/FGFR1. E Representative hematoxylin-eosin (H&E) staining images of orthotopic implantation. Scale bar, 1 mm, n = 6. F Representative IHC images of the positive expression levels of Ki67(1:5000), OTUD4(1:300), CDK1(1:400), FGFR1(1:400) and p-BRAF(1:100). Scale bar, 50 μm. Data were expressed as the mean ± SD, n = 3. Student’s t-test was performed to analyze significance. *P < 0.05, **P < 0.01, ***P < 0.001. G Scheme for the regulatory mechanism of OTUD4 on CDK1.

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