Fig. 7: RC48 plus GEM synergistically inhibited CRC tumor growth in mouse CDX and PDX models. | Cell Death & Disease

Fig. 7: RC48 plus GEM synergistically inhibited CRC tumor growth in mouse CDX and PDX models.

From: Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer

Fig. 7

Tumor growth curve, transplanted tumor weight, and images are displayed in COLO205 (A−C) and HCT116 (D−F) CDX models. G Images of immunohistochemical staining for Ki67 in COLO205 and HCT116 CDX mouse xenograft tumors. Tumor growth curve, transplanted tumor weight, and images were evaluated in CRC054 (H–M) and CRC082 (K–M) PDX models. N Images of immunohistochemical staining for Ki67 in CRC054 and CRC082 PDX mice xenograft tumors. O Images of immunofluorescence TUNEL of CRC054 and CRC082 PDX mouse xenograft tumors. RC48 and vehicle groups were intravenously administered and GEM groups were intraperitoneally administered. IHC Images captured at 400×magnification, Scale bars = 20 µm. TUNEL Images captured at 200×magnification, respectively. Scale bars = 500 µm. And statistical significance was assessed by unpaired T-test (*p < 0.05; **p < 0.01; ***p < 0.001).

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