Fig. 6: In vivo effect of GlyT1 inhibitor on tumor volume and vasculogenesis.
From: Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice
A Tumor size in GM and GM/ABX mice with or without GlyT1 inhibitor, n = 5–9, pooled from two experiments. Data are presented as the mean ± SD **p < 0.01, ***p < 0.001, one-way ANOVA followed by Tukey’s multiple comparison test. B Representative images of brain coronal slices, scale bar = 1 mm. C Representative confocal images of CD34 (magenta) in GM and GM/ABX tumor core area. Hoechst staining (blu) for nuclei visualization Scale bar: 50 μm. D Scatter dot plots showing quantification of CD34 signal expressed as the percentual area occupied by fluorescent CD34 staining in GM (n = 18/3 slices/mice), GM/ABX (n = 18/3 slices/mice), GM + GlyT1 inh (n = 19/3 slices/mice), GM/ABX + GlyT1 inh (n = 20/3 slices/mice) mice versus total field of view (FOV) Data are presented as the mean ± SD ***p < 0.001; one-way ANOVA followed by Tukey’s multiple comparison test.
