Fig. 3: The absence of Agrin leads to progressive muscle function deficits.

Grip strength (A) and running distance (B) of control and cKO mice at 3 and 12 months of age. n = 15 mice per group. Comparable single twitch and tetanic forces between control and cKO mice at 3 months (C–E) and 12 months (F–H) of age. D, G Representative tetanic curve. n = 15 mice per group. *p < 0.05, **p < 0.01, ****p < 0.0001.