Fig. 7: Yap signaling and α-DG were involved in Agrin deficiency and sarcopenic muscles. | Cell Death & Disease

Fig. 7: Yap signaling and α-DG were involved in Agrin deficiency and sarcopenic muscles.

From: Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice

Fig. 7

A Western blot analysis of Agrin mediated pathways in skeletal muscles from Agrin-deficient and aged mice. B Quantification of data in A. n = 3 mice per group. C qRT‒PCR analysis of Yap downstream targets in skeletal muscles from Agrin-deficient and aged mice. n = 5 mice per group. D Representative images of Yap (red) in young (2-3 months) and aged (18–20 months) myoblast. E Quantification of data in D, N > C refers to predominant nuclear YAP. n = 7 mice per group, Scale bar = 50 μm.*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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