Fig. 1: Ferroptosis and carbohydrate metabolism.
From: Metabolism-regulated ferroptosis in cancer progression and therapy
Carbohydrate metabolism mainly contain glycolysis, TCA cycle and pentose phosphate pathway. The substrates and enzymes in these pathways affect ferroptosis in various mechanism. SLC7A11 solute carrier family 7 member 11, SLC3A2 solute carrier family 3 member 2, HK2 hexokinase 2, SIRT2 sirtuin 2, TRIM36 trigred motif 36, G6P glucose-6-phosphate, PKM2 pyruvate kinase M2, Cdc25 cell division cycle 25, GPX4 glutathione peroxidase 4, PLOOH phospholipid hydroperoxides, PLOH phospholipid alcohols, GSH reduced glutathione, GSSG glutathione disulfide, NADPH reduced nicotinamide adenine dinucleotide phosphate, PDK4 pyruvate dehydrogenase kinase 4, PDH pyruvate dehydrogenase complex, αKG alpha-ketoglutaric acid, KGDH alpha-ketoglutarate dehydrogenase complex, SDH succinate dehydrogenase, FH fumarate hydratase, TCA cycle tricarboxylic acid cycle, ME1 malic enzyme 1, TXNRD1 thioredoxin reductase 1, G6P glucose 6-phosphate, R5P ribose 5-phosphate, G6PD glucose-6-phosphate dehydrogenase, POR cytochrome p450 oxidoreductase, FSP1 ferroptosis suppressor protein 1, CoQ ubiquinone, CoQH2 ubiquinol, NOXs NADPH oxidases, O2 oxygen, O2.− superoxide anion, H2O2 hydrogen peroxide, HO. hydroxyl ion (Created with BioRender.com).
