Fig. 2: PQR309 suppresses the growth, invasion, and migration and enhances apoptosis in NPC cells. | Cell Death & Disease

Fig. 2: PQR309 suppresses the growth, invasion, and migration and enhances apoptosis in NPC cells.

From: PQR309, a dual PI3K/mTOR inhibitor, synergizes with gemcitabine by impairing the GSK-3β and STAT3/HSP60 signaling pathways to treat nasopharyngeal carcinoma

Fig. 2

A, B PQR309 inhibits colony formation of NPC cells in a dose-dependent way. C, D Annexin V/PI analysis of CNE1 and HNE1 cells treated with different concentrations of PQR309. E, F Western blotting was applied to detect cleaved caspase-3 and capase-9 levels (apoptotic indexes). G, H Invasion assays of CNE1 and HNE1 cells treated with different concentrations of PQR309. I, J Migration assays of CNE1 and HNE1 cells treated with different concentrations of PQR309. K, L Western blotting was applied to detect EMT markers in CNE1 and HNE1 cells treated with different concentrations of PQR309. All *P < 0.05, **P < 0.01, ***P < 0.001. The error bars represent the standard deviations of three independent experiments. NPC Nasopharyngeal carcinoma, EMT Epithelial-mesenchyme transition.

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