Fig. 7: Potential mechanism of the antineoplastic role of PQR309 and gemcitabine in nasopharyngeal carcinoma. | Cell Death & Disease

Fig. 7: Potential mechanism of the antineoplastic role of PQR309 and gemcitabine in nasopharyngeal carcinoma.

From: PQR309, a dual PI3K/mTOR inhibitor, synergizes with gemcitabine by impairing the GSK-3β and STAT3/HSP60 signaling pathways to treat nasopharyngeal carcinoma

Fig. 7

PQR309 sensitized NPC to gemcitabine by increasing caspase-dependent pathway apoptosis, blocking GSK-3β and STAT3/HSP60 signaling pathways, and inhibiting EMT. NPC Nasopharyngeal carcinoma; HSP60 Heat shock protein 60, EMT Epithelial-mesenchyme transition.

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