Fig. 1: Gene set enrichment analysis reveals mitochondrial alterations in PD patients that parallel disease progression severity. | Cell Death & Disease

Fig. 1: Gene set enrichment analysis reveals mitochondrial alterations in PD patients that parallel disease progression severity.

From: Orthogonal analysis of mitochondrial function in Parkinson’s disease patients

Fig. 1

A iPD in the PPMI cohort was stratified based on the evolution of the UPDRS-III score between visit 1 and visit 8. B GSEA indicates that multiple mitochondrial pathways are downregulated in iPD, at visit 1. Deregulation of mitochondrial pathways was not detected at visit 8 when pathways related to reactive oxygen species were instead upregulated. C At visit 1, patients who will develop more severe symptoms display deregulation in a higher number of mitochondrial pathways.

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