Fig. 7: Sulfasalazine with POLQ inhibition efficiently facilitates treatment in gastric cancer. | Cell Death & Disease

Fig. 7: Sulfasalazine with POLQ inhibition efficiently facilitates treatment in gastric cancer.

From: POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase

Fig. 7

A Schematic of subcutaneous xenograft model treated with vehicle, novobiocin, sulfasalazine, or sulfasalazine in combination with novobiocin (n = 4). B Morphological images of the tumors. C The weights of subcutaneous tumors in indicated mice. D Mice weights were recorded after vehicle, novobiocin, sulfasalazine, or sulfasalazine in combination with novobiocin treatment. E, F IHC staining of DHODH, 4HNE, and MKi67 in subcutaneous tumors derived from indicated mice (scale bar = 50 μm). The expression of PTGS2 (G), CD24, and CD44 (H) in subcutaneous tumors from indicated mice. I, J BLI and images of intraperitoneal tumor formation model treated with vehicle, novobiocin, sulfasalazine, or sulfasalazine in combination with novobiocin (n = 4). Results are shown as mean ± SD. *P < 0.05; **P <0.01; ***P < 0.001; ns not significant.

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