Fig. 2: The Wnt/β-catenin signaling is involved in NURR1-overexpressed prostate cancer. | Cell Death & Disease

Fig. 2: The Wnt/β-catenin signaling is involved in NURR1-overexpressed prostate cancer.

From: Nuclear receptor NURR1 functions to promote stemness and epithelial-mesenchymal transition in prostate cancer via its targeting of Wnt/β-catenin signaling pathway

Fig. 2

A Bubble plot displaying Gene Set Enrichment Analysis (GSEA) of RNA-sequencing data of the DU 145-NURR1 and -Vector infectants. The result reveal that the Wnt/β-catenin signaling is the most significantly enriched pathway in NURR1-overexpression (NURR1) group compared to the control (Vector) group. B GSEA results of enriched Wnt/β-catenin signaling in DU 145-NURR1 and -Vector infectants, as well as in NURR1-High and -Low groups. C Bubble plot showing GSEA of RNA-sequencing data of the patients from TCGA database that are separated into NURR1-High and Low groups based on their ranked expression level of NURR1. The result reveal that the Wnt/β-catenin signaling is significantly enriched in NURR1-High group compared to the NURR1-Low group. D Expression analysis of a prostate adenocarcinoma dataset (PRAD) from TCGA database reveals that NR4A2 exhibits a positive expression correlation with CTNNB1 in primary prostate cancer tissues (https://www.cancer.gov/tcga). E, F RT-qPCR analysis of CTNNB1 (β-catenin) expression in DU 145-NURR1 infectants and DU 145-shNURR1 infectants. Results showed that CTNNB1 exhibited a significant upregulation in DU 145-NURR1 infectants and conversely downregulation in DU 145-shNURR1 infectants. *P < 0.05 versus vector or scramble controls.

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