Fig. 4: TGM3 inhibits EMT progression via PI3K-AKT signaling in cSCC cells. | Cell Death & Disease

Fig. 4: TGM3 inhibits EMT progression via PI3K-AKT signaling in cSCC cells.

From: Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation

Fig. 4

A, B KEGG pathways analysis of differentially expressed genes (DEGs) revealed a notable increase in the activity of the PI3K-AKT signaling pathway and Epithelial-mesenchymal transition (EMT) progression in TGM3-knockdown A431 cells. C GO pathway enrichment analysis of DEPs revealed marked up-regulation of key molecules involved in EMT progression. D Effects of TGM3 knockdown and overexpression on PI3K-AKT signaling and KRT14 and EMT markers in SCL-1 and A431 cells. E Effect of TGM3 knockdown on PI3K-AKT signaling in subcutaneous A431 xenograft tumor model. F Effect of TGM3 knockdown on the expression of KRT14 and EMT markers in subcutaneous A431 xenograft tumor model. All experiments were repeated at least three times.

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