Fig. 4: The ΔC3 domain of FBXL8 interacts with the C-terminal domain of Snail1. | Cell Death & Disease

Fig. 4: The ΔC3 domain of FBXL8 interacts with the C-terminal domain of Snail1.

From: FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation

Fig. 4

A Co-IP assay of endogenous FBXL8 and Snail1 in rat CFs. B, C Co-IP assays of the exogenous interaction between HA-FBXL8 and Flag-Snail1 in HEK293T cells transfected with the indicated plasmids. D Representative confocal images of the colocalization of FBXL8 and Snail1 in CFs treated with TGFβ. E Schematic model of deletion mutants of FBXL8. F Co-IP analysis of the binding regions of FBXL8 and Snail1. G Co-IP analysis of the binding regions of Snail1 and FBXL8.

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