Fig. 8: Schematic of the proposed model for the FBXL8-mediated proteasome degradation of Snail1 in cardiac fibrosis. | Cell Death & Disease

Fig. 8: Schematic of the proposed model for the FBXL8-mediated proteasome degradation of Snail1 in cardiac fibrosis.

From: FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation

Fig. 8

FBXL8 interacts with Snail1 and targets Snail1 for ubiquitin-proteasome degradation response to MI. In response to TGFβ stimulation and MI, downregulation of FBXL8 expression in CFs leads to stabilization of Snail1, thereby activating the RhoA/α-SMA pathway, inducing myofibroblast differentiation and the progress of cardiac fibrosis following MI.

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