Table 2 Involvement of miRNAs and autophagy in cancer biology.
From: The emerging roles of miRNA-mediated autophagy in ovarian cancer
Effect on autophagy | Name | miRNA expression regulation | miRNA functions | Tested cell line (tissue origin) | Ref. |
|---|---|---|---|---|---|
Inhibition | miRNA-200c | Upregulated | Inhibition of cell proliferation | SKOV3/Olaparib | [136] |
Inhibition | miRNA-125a-3p | Upregulated | Inhibition of cell proliferation, migration, and invasion, induction of cellular senescence | SKOV3 and A2780 | [137] |
Inhibition | miRNA-1305 | Downregulated | Inhibition of cell proliferation and tumor growth | Ovarian tumors | [138] |
Inhibition | miRNA-194-5p | Upregulated | Inhibition of cell viability, promotion of apoptosis | A2780/DDP and SKOV3/DDP | [139] |
Inhibition | miRNA-141-3p | Downregulated | Inhibition of cell proliferation, migration, and invasion | SKOV3 and A2780 | [140] |
Activation | miRNA-144 | Downregulated | Enhancement of cell viability | KGN | [141] |
Inhibition | miRNA-30b-5p | Upregulated | Inhibition of cell proliferation, promotion of apoptosis | Ovarian granulosa cell | [142] |
Inhibition | miRNA-21 | Upregulated | Inhibition of cell growth, induction of apoptosis | AGS/DDP | [143] |
Inhibition | miRNA-486 | Upregulated | Inhibition of cell viability and proliferation, induction of apoptosis | Ovarian granulosa cell | [144] |
Inhibition | miRNA-29c‐3p | Upregulated | Inhibition of cell migration and invasion | SKOV3 | [145] |
Inhibition | miRNA-let-7b/7c-5p | Upregulated | Inhibition of tumor growth | HEY and SKOV3 | [146] |
Inhibition | miRNA-654 | Upregulated | Inhibition of cell survival, induction of apoptosis | Mouse OGCs | [147] |
Inhibition | miRNA-29c-3p | Upregulated | Inhibition of cell proliferation | SKOV3/DDP A2780/DDP | [135] |
Inhibition | miRNA-199a | Downregulate | Inhibition of cell proliferation and invasion | SKOV3/DDP | [134] |
Inhibition | miRNA-1301 | Upregulated | Inhibition of cell proliferation and invasion | SKOV3/DDP | [133] |
Inhibition | miRNA-506-3p | Upregulated | Inhibition of cell proliferation, promotion of apoptosis | SKOV3/CBP and A2780/CBP | [76] |
Inhibition | miRNA-219-5p | Upregulated | Inhibition of cell proliferation, induction of apoptosis | A2780/DDP and SKOV3/DDP | [79] |
Inhibition | miRNA-3127-5p | Downregulated | Inhibition of cell viability, migration, and invasion | SKOV3, A2780, SKOV3/PTX and A2780/PTX | [78] |
Inhibition | miRNA-125b | Upregulated | Inhibition of cell proliferation, induction of apoptosis | COC1/DDP | [118] |
Inhibition | miRNA-29b-3p | Downregulate | Inhibition of cell viability and proliferation | SKOV3/PTX and A2780/PTX | [129] |
Inhibition | miRNA-4478 | Upregulated | Inhibition of cell proliferation | ES-2 and SKOV3 | [69] |
