Table 3 The impact of autophagy-related miRNAs on ovarian cancer chemotherapy and radiotherapy.
From: The emerging roles of miRNA-mediated autophagy in ovarian cancer
Effect on autophagy | Name | miRNA expression regulation | Resistance to treatment | Effect on radiotherapy/chemotherapy | Tested cell line (tissue origin) | Ref. |
|---|---|---|---|---|---|---|
Inhibition | miRNA-125b | Upregulated | Cisplatin | Sensitized | COC1/DDP | [118] |
Inhibition | miRNA-133a | Upregulated | Cisplatin | Sensitized | A2780/DDP and SKOV3/DDP | [116] |
Inhibition | miRNA-219-5p | Upregulated | Cisplatin | Sensitized | A2780/DDP and SKOV3/DDP | [79] |
Inhibition | miRNA-299 | Upregulated | Radiotherapy | Sensitized | Caov3 | [148] |
Inhibition | miRNA-3127-5p | Downregulated | paclitaxel | Sensitized | SKOV3, A2780, SKOV3/PTX and A2780/PTX | [78] |
Inhibition | miRNA-4478 | Upregulated | Radiotherapy | Sensitized | ES-2 and SKOV3 | [69] |
Inhibition | miRNA-506-3p | Upregulated | carboplatin | Sensitized | SKOV3/CBP and A2780 / CBP | [76] |
Inhibition | miRNA-1301 | Upregulated | Cisplatin | Sensitized | SKOV3/DDP | [133] |
Inhibition | miRNA-29c-3p | Upregulated | Cisplatin | Sensitized | SKOV3/DDP A2780/DDP | [135] |
Inhibition | miRNA-29b-3p | Downregulate | paclitaxel | Sensitized | SKOV3/PTX and A2780/PTX | [129] |
Inhibition | miRNA-199a | Downregulate | Cisplatin | Sensitized | SKOV3/DDP | [134] |
Inhibition | miRNA-200c | Upregulated | Olaparib | Sensitized | SKOV3/Olaparib | [136] |
Inhibition | miRNA-588 | Downregulate | Radiotherapy | Sensitized | SKOV3 and A2780 | [149] |
Inhibition | miRNA-374a | Downregulate | Cisplatin | Sensitized | A2780/DDP | [150] |
Inhibition | miRNA-770-5p | Upregulated | Cisplatin | Sensitized | A2780/DDP and SKOV3 / DDP | [151] |
Inhibition | miRNA-1299 | Upregulated | paclitaxel | Sensitized | SKOV3/PTX | [152] |
Activation | miRNA-181d | Upregulated | Cisplatin | Resistant | A2780/DDP | [153] |
Activation | miRNA-210 | Upregulated | Radiotherapy | Resistant | OVCAR3 and SKOV3 | [106] |
Activation | miRNA-214 | Upregulated | Radiotherapy | Resistant | SKOV3 and IOSE80 | [105] |
Activation | miRNA-27a | Upregulated | paclitaxel | Resistant | A2780、HO8910、OVCAR3 and PEO-1 | [154] |
Activation | miRNA-194-5p | Upregulated | Cisplatin | Resistant | A2780/DDP and COC1/DDP | [155] |
