Fig. 2: Iron promotes ovarian cancer malignancy by enhancing cell survival, spheroid formation, and migration. | Cell Death & Disease

Fig. 2: Iron promotes ovarian cancer malignancy by enhancing cell survival, spheroid formation, and migration.

From: Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis

Fig. 2

A Spheroid-forming assay assessing the impact of varying FeCl3 concentrations on the capacity of ovarian cancer cells to form spheroids. B Spheroid-forming assay evaluating the effects of FeCl3 and DFO on the spheroid-forming ability of ovarian cancer cells. C, D Statistical bar charts for (A) and (B). E Assessment of the impact of FeCl3 on the migratory capacity of ovarian cancer cells using a wound healing assay over 24 h. F, G Ovarian cancer cells were treated with FeCl3 for 24 h and 48 h, and then cellular apoptosis was analyzed by flow cytometry. Data are presented as the mean ± standard deviation (SD) from three independent experiments. ****p ≤ 0.0001, ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05 and ns p > 0.05.

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