Fig. 8: Iron chelator enhances carboplatin sensitivity in ovarian cancer in vivo.

A The In-vivo Xtreme live imaging system was used to track tumor progression in mice treated with carboplatin and/or DFO. B Changes in mouse body weight after carboplatin and/or DFO treatments during the experiment. Time refers to the initiation of the treatments. C Intraperitoneal ascites volume in different experimental groups(n = 4). D Survival curves of the mouse throughout the experiment. E In vivo animal imaging system was used to track tumor progression in mice treated with carboplatin and/or Triapine. F Changes in mouse body weight after carboplatin and/or Triapine treatments during the experiment. Time refers to the initiation of the treatments. G Intraperitoneal ascites volume in different experimental groups(n = 5). H Survival curves of the mouse throughout the experiment. Data are presented as the mean ± Standard Error of the Mean (SEM) from three independent experiments. ****p ≤ 0.0001, ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05 and ns p > 0.05.