Fig. 4: C10 induces ER stress response.
From: Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress
a Differentially expressed mRNA from RNAseq (black) or qPCR (gray) of SYO1 cells treated with the different S2L. Data are presented as mean ± SD; n = 3. Percent of cell death from Cell TiterGlo assay measuring the viability of SYO1, OVCAR8, and MiaPaCa-2 cells pretreated with avasimibe (b), CI-976 (c), thapsigargin (d), or 4-PBA (e) for 2 h then treated with C10 for 24 h. Data represent mean ± SD; n = 3. ns = p > 0.05; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001.
