Fig. 7: FOXP4’s oncogenic potential in OV cells requires PTK7. | Cell Death & Disease

Fig. 7: FOXP4’s oncogenic potential in OV cells requires PTK7.

From: FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development

Fig. 7

A The FOXP4 retrovirus was infected into A2780 cells stably expressing sh-PTK7, and A2780 cell lysates of pLKO, FOXP4, and FOXP4+sh-PTK7 were immunobloted with the indicated antibodies. B The cell growth curve of cells from (A), n = 3. ***p < 0.001. C Incorporation of BrdU in cells from (A) was measured by ELISA, n = 3. *p < 0.05, **p < 0.01. D Clonogenic assay of cells in (A), n = 3. ***p < 0.001. E Relative invasion rates of cells in (A) in a transwell assay, n = 3. ***p < 0.001. F A2780 cells stably expressing EV or FOXP4 or FOXP4 infected with sh-PTK7 in FOXP4 were inoculated subcutaneously in nude mice, respectively, and the folded line graphs indicate the average volume of tumors over time, n = 6. ***p < 0.001. G Image representing the tumor on day 28, n = 6. H Bar graphs represent the weight of the tumor on day 28, n = 6. ***p < 0.001.

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