Fig. 1: TIR signaling is activated in CSCs and cisplatin-resistant EOC. | Cell Death & Disease

Fig. 1: TIR signaling is activated in CSCs and cisplatin-resistant EOC.

From: Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer

Fig. 1

A Viability assay of A2780 and C30 cells treated with cisplatin. B Quantification of spheroid formation for A2780 and C30 cells. C Hierarchal clustering heatmap of RNA sequencing data from A2780 and C30 cells grown as 2D and 3D cultures. D Volcano plot comparing log2 fold enrichment of genes highly expressed in C30 and A2780 cells grown in 2D. E Volcano plot comparing gene enrichment of highly expressed in A2780 cells grown in 3D and 2D. F List of IPA-activated pathways in C30 cells. Red bars indicate commonly activated pathways. *Indicates TIR-related signaling pathways. G List of IPA-activated pathways in A2780 cells grown in 3D. Red bars indicate commonly activated pathways as in (F). H Venn diagram comparing IPA-activated pathways from (F, G).

Back to article page