Fig. 2: Application of different types of CAR T cell therapy in urinary system tumors. | Cell Death & Disease

Fig. 2: Application of different types of CAR T cell therapy in urinary system tumors.

From: Molecular understanding and clinical outcomes of CAR T cell therapy in the treatment of urological tumors

Fig. 2

A The fourth-generation of CAR T (CD28) targeted CAIX to secrete anti-PD-L1 antibody to block T cells exhaustion in RCC. B The second-generation of CAR T (CD27) targeted CD70 in RCC. C The third-generation of CAR T (CD28 and 4-1BB) targeted c-Met in RCC. D The second-generation of CAR T (4-1BB) targeted CAIX in RCC. E The second-generation of CAR T (CD28) targeted PD-1 in BCa. F The second-generation of CAR T (CD28) targeted MUC1 in BCa. G The second-generation of CAR T (CD28) targeted EGFR in BCa. H The second-generation of CAR T (4-1BB) targeted PSMA in PCa. I The second-generation of CAR T (CD28) targeted PSMA in PCa. J The fourth-generation of CAR T (IL-23mAb-PSMA-CARs) was more effective in PCa. K The second-generation of CAR T (4-1BB) targeted PSCA in PCa. (L). The second-generation of CAR T (4-1BB) targeted STEAP1 in PCa. M The second-generation of CAR T (CD28) targeted B7-H3 in PCa.

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