Fig. 3: USP7 promoted YY1 stabilization by deubiquitinating it through the K63 linkage. | Cell Death & Disease

Fig. 3: USP7 promoted YY1 stabilization by deubiquitinating it through the K63 linkage.

From: The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis

Fig. 3

A, B The effect of USP7 on YY1 ubiquitination in LOVO (A) and DLD1 (B) cells treated with siUSP7. C, D The effect of USP7 on YY1 ubiquitination in LOVO (C) and DLD1 (D) cells treated with siUSP7 followed by transfection of Flag-YY1 and HA-Ub. E–G K48-only and K63-only HA-Ub plasmids alone or cotransfected with siUSP7 into HEK 293T, LOVO, and DLD1 cells to detect YY1 ubiquitination by CoIP. H Schematic representation of YY1 truncated mutaions. I The YY1 truncated mutation plasmids were transfected into HEK 293T to detect their interaction with USP7.

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