Table 2 Cox regression analysis of risk factors for cancer-related death in lung cancer patients.

From: IL-33/NF-κB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer

Characteristics

Univariate analysis

Multivariate analysis

HRa (95% CIb)

p-valuec

HR (95% CI)

p-valuec

CD206+Rab37+ST2L+ cells (%)d

<0.6%

1.00

 

1.00

 

≥0.6%

2.824(1.375–5.801)

0.005

2.311 (1.096–4.875)

0.028

Age

<65

1.00

 

–f

 

≥65

0.437 (0.187–1.019)

0.055

–f

–f

Gender

Female

1.00

 

–f

 

Male

1.090 (0.544–2.184)

0.809

–f

–f

Tumor stage

I-II

1.00

 

1

 

III-IV

2.636 (1.251–5.555)

0.011

2.103 (0.971–4.557)

0.060

T statuse

T1-2

1.00

 

–f

 

T3-4

1.680 (0.744–3.791)

0.212

–f

–f

N statuse

≤N1

1.00

 

–f

 

>N1

1.753 (0.784–3.920)

0.171

–f

–f

M statuse

M0

1.00

 

1.00

 

≥M1

2.721 (1.084–6.830)

0.033

1.450 (0.542–3.875)

0.459

  1. aHR Hazard ratio.
  2. bCI Confidence interval.
  3. cBold values indicate statistical significance (p < 0.05).
  4. dPatient with CD206+Rab37+ST2L+cells (%) ≥ 0.6% of ROIs was defined as high expression.
  5. eT status: primary tumor; N status: lymph node metastasis; M status: distant metastasis.
  6. fVariables without significant HR in the univariate analysis were not included in the multivariate analysis.
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