Fig. 3: Absence of STAT3β accelerates disease progression in an MLL-AF9-dependent mouse model. | Cell Death & Disease

Fig. 3: Absence of STAT3β accelerates disease progression in an MLL-AF9-dependent mouse model.

From: A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia

Fig. 3

A 200 000 Venus+ cells were intravenously (i.v.) transplanted into immunocompromised NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice. B Kaplan-Meier plot of mice receiving STAT3β-deficient or WT leukemia cells (3 independent experiments, median survival: WT = 78 days; Δβ = 64 days). Log-rank (Mantel-Cox) test was performed to analyze the survival difference between the two groups (P = 0.0055). C WBC count of diseased animals at the time point of euthanasia (n = 15). D Representative pictures of spleens from diseased animals. E Spleen-to-body weight of diseased animals (n = 15, ctrl: n = 2). F Flow cytometry quantification of myeloid markers on leukemia cells isolated from the BM and SP of each animal (n = 24, BM and SP pooled from 12 animals) and representative dot plots. Further statistical analysis was performed using Student’s t test and indicated as p ≤ 0.05:*. Error bars represent means ± SD. (WBC white blood cell).

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