Fig. 7: High expression of STAT1/IFN-inducible genes is associated with low STAT3β expression and adverse outcomes in AML patients. | Cell Death & Disease

Fig. 7: High expression of STAT1/IFN-inducible genes is associated with low STAT3β expression and adverse outcomes in AML patients.

From: A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia

Fig. 7

A RT-qPCR analysis of STAT3 isoform expression in 79 AML patient samples. A low STAT3β/α mRNA ratio correlates with poor OS. Patients were stratified according to the best cut-off value. Statistical analysis was performed using log-rank (Mantel-Cox) test. B RT-qPCR of STAT3α and STAT3β (normalized to GAPDH) in patients with a low or high STAT3β/α ratio (n = 79). Data were compared using the Student’s t test. C STAT1 and UBE2L6 expression in patients with a low or high STAT3β/α ratio (n = 79). Data were compared using the Student’s t test. D KM Plotter analysis of RNA sequencing data of AML patients showing a correlation between high expression of GBP2, GPB4, and UBE2L6 with OS. Patients were stratified according to the best cut-off value. (kmplot.com), status: 15.01.2024. Statistical analysis was performed using log-rank (Mantel-Cox) test. p ≤ 0.05:*, ≤0.01:**, ≤0.001:***.

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