Fig. 2: ORC6 overexpression in glioma tissues of locally treated patients and different glioma cells.

The expression levels of ORC6 in glioma tissues compared to normal tissues, sourced from the Rembrandt database, were shown (A). The Kaplan-Meier Survival analysis based on ORC6 expression among glioma patients of the Rembrandt database was shown (B). ORC6 expression in glioma tissues according to different glioma grades from the Rembrandt database was shown (C). The Kaplan-Meier Survival analysis derived from the Chinese Glioma Genome Atlas (CGGA) database, illustrating the relationship between ORC6 expression and survival among glioma patients, was shown (D). CGGA database demonstrated the correlation between ORC6 expression and glioma grade (E) or IDH status (F) in glioma patients. ORC6 mRNA and protein expression in glioma tissues (“T”) versus adjacent normal brain tissues (“N”) from twenty (n = 20) local high-grade glioma (HGG) patients were shown (G–I). ORC6 mRNA and protein expression in primary human astrocytes (“Astrocytes1/2”), immortalized (A172) or primary (“P1,” “P2,” “P3”) glioma cells was presented (J and K). Data were presented as mean ± standard deviation (SD) (G–K). *indicate statistical significance (P < 0.05) compared to “N” tissues or “Astrocytes1”.