Fig. 6: Obesity impairs fatty acid metabolism of human MSCs.

Proliferation (A percent phase object confluence unit) and migration (B Colorimetric Cell Assay) of Non-obese and Obese-MSCs (n = 5 each). C Liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomic analysis of the fatty acid (FA) metabolites eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and linolenic, myristic, palmitoleic, arachidonic, linoleic, palmitic, oleic, elaidic, and stearic acids in non-obese- and Obese-MSCs untreated or treated with Bobcat339 or DMαKG (n = 5 each). *p value < 0.05 vs. Non-obese-MSCs (untreated). NS: non-significant (p > 0.05).