Fig. 3: Transcriptomic and metabolomic exploration upon MAL2 suppression in ICC cells. | Cell Death & Disease

Fig. 3: Transcriptomic and metabolomic exploration upon MAL2 suppression in ICC cells.

From: MAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing

Fig. 3

A A heatmap displays shifts in gene expression subsequent to MAL2 silencing in ICC cells. B, C Pathway enrichment of KEGG and GO among the diverse genes expressed. D A Circos plot illustrating the associations among various disparate metabolites. E Classification and tallying of distinctive metabolites in every control group, based on their structure and function, are demonstrated, presenting classification data from both KEGG and HMDB databases. F A Sankey diagram showing the trajectories of downregulated metabolite data flow across multiple pathways. G KEGG pathway investigation pinpointing the key pathways where these altered metabolites are heavily represented.

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