Fig. 4: HOXD10 overexpression inhibits ferroptosis and oxidative stress in TGF-β1-induced HK-2 cells.
From: HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis
A Iron concentrations in each HK-2 cells group. B DCF staining showed that HOXD10 overexpression plasmids alleviated TGF-β1-induced ROS generation in HK-2 cells (×200). Bar = 100 μm. C C11 staining showed that HOXD10 overexpression plasmids alleviated TGF-β1-induced lipid ROS generation in HK-2 cells (×200). Bar = 100 μm. D MitoSOX staining revealed that HOXD10 overexpression plasmids attenuated TGF-β1-induced mitochondrial ROS generation in HK-2 cells (×200). Bar = 100 μm. In all panels, the data are representative of three independent experiments. Data are presented as the mean ± SD. **P < 0.01, NS not significant.
