Fig. 4: JNK1 is an upstream phosphokinase of FOXQ1 phosphorylation. | Cell Death & Disease

Fig. 4: JNK1 is an upstream phosphokinase of FOXQ1 phosphorylation.

From: Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma

Fig. 4

A Possible upstream phosphorylated kinases of FOXQ1 predicted by PhosphoNET database (http://www.phosphonet.ca/). B Effect of sorafenib (10 μM) on JNK phosphorylation. C, D Detection of JNK1 binding to FOXQ1 by immunoprecipitation. E The effect of JNK1 expression on the phosphorylation of FOXQ1 at serine 248 (S248). F In vitro kinase assays verify the changes in phosphorylation of FOXQ1 when FOXQ1 was incubated with JNK1 or DB07258.

Back to article page