Fig. 9: Schematic diagram of molecular mechanism of FOXQ1 regulating ferroptosis in HCC. | Cell Death & Disease

Fig. 9: Schematic diagram of molecular mechanism of FOXQ1 regulating ferroptosis in HCC.

From: Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma

Fig. 9

Sorafenib phosphorylates JNK1, and the phosphorylated JNK1 enters the nucleus and binds to FOXQ1 to further activate the phosphorylation at serine 248 site of FOXQ1. Then the phosphorylated FOXQ1 binds to the promoter region of ETHE1 and transcriptionally activates ETHE1 to inhibit ferroptosis.

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