Table 1 Ferroptosis-related inducers.
Mechanisms | Ferroptosis-related inducers | Functions | Reference. |
|---|---|---|---|
Inhibit GPX4/GSH | Ras-selective Lethal Small Molecule 3 (RSL3) | Inhibit GPX4 | [341] |
DMOCPTL | GPX4 ubiquitination | [331] | |
FINO2 | Indirectly inhibits GPX4, directly oxidizes iron | [332] | |
L-buthionine (S,R)-Sulfoximine (BSO) | Reduce glutathione-dependent peroxidase activity | [333] | |
Legumain | Inhibit GPX4 | [334] | |
APR-246 | Deactivate SLC7A11 or GPX4 | [334] | |
FIN56 | Promote GPX4 degradation | [335] | |
Artesunate (ART) | Inhibit GPX4 | [336] | |
ML210/ ML162/JKE-1674/ | Inhibit GPX4 | [337] | |
Increase intracellular iron and induce lipid peroxidation | Lipopolysaccharide (LPS) | Inhibits GPX4 and induces ferroautophagy | [338] |
High-glucose | Increase MDA levels, ROS levels and intracellular iron ion levels | [339] | |
EF24 | Increase MDA levels, ROS levels and intracellular iron ion levels | [340] | |
Angiotensin II (Ang II) | Increase ROS levels and inhibit GSH levels | [341] | |
Oxidized-low density lipoprotein (ox-LDL) | Increase ROS, intracellular iron ion levels, and induce lipid peroxidation | [342] |
