Fig. 1: YME1L overexpression in NPC tissues and cells.
From: Expression and functional implications of YME1L in nasopharyngeal carcinoma
YME1L mRNA (A) and protein (B and C) expression in NPC tumor tissues (“T”, n = 20) and their corresponding matched adjacent normal nasopharynx epithelial tissues (“N”, n = 20) were displayed, with quantified results provided. The immunohistochemistry (IHC) images depicting YME1L expression in the described human tissues were quantified, with IHC score results provided (D). Tissue immunofluorescence images, displaying YME1L (green fluorescence), the mitochondrial marker MitoTracker (red fluorescence), and nuclear DAPI staining (blue fluorescence) within the NPC tumor tissue and the adjacent normal epithelial tissue of Patient-1# were presented (E), and the normalized fluorescence intensity was quantified (E). YME1L mRNA expression (F) and protein expression (in both mitochondrial fraction lysates and mitochondria-null lysates G) were demonstrated in primary human NPC cells (“pNPC-1”, “pNPC-2”, “pNPC-3”, and “pNPC-4”) and primary human nasal epithelial cells (“pHNEpC-1” and “pHNEpC-2”) as described. The numerical values were mean ± standard deviation (SD). *P < 0.05 vs. “N” tissues or “pHNEpC-1” cells. Scale bar = 100 μm.
