Fig. 7: YME1L silencing impedes NPC xenograft growth in nude mice.
From: Expression and functional implications of YME1L in nasopharyngeal carcinoma
The pNPC-1 xenograft-bearing nude mice were subject to intratumoral injection of the described virus, tumor volumes (in mm3, A) and the animal weights (in G, D) were recorded every six days. The estimated daily pNPC-1 xenograft growth, in mm3 per day, was also shown (B). All pNPC-1 xenografts were isolated at Day-42 and weighted (C). Expression of YME1L mRNA and listed proteins in the described pNPC-1 xenograft tissues was tested (E–G, L, M and O). The mitochondrial complex-1 activity (H), ATP contents (I), GSH/GSSG ratio (J), TBAR activity (K) and Caspase-3 activity (N) in tissue lysates were examined as well. The pNPC-1 xenograft sections were also subject to fluorescence detection of TUNEL-positive nuclei (P). The data were presented as mean ± standard deviation (SD). In A–D, ten mice were in each group (n = 10). For E–P, five random tissue pieces in each xenograft were tested (n = 5). *P < 0.05 vs. “AAV-shC” group. Scale bar = 100 μm.
