Fig. 2: Age-related redistribution of adipose tissues.
From: Aging and homeostasis of the hypodermis in the age-related deterioration of skin function
A decrease in energy expenditure with age leads to depot redistribution among visceral, subcutaneous, and other adipose tissues, in parallel with the functional decline of adipocyte progenitors, defective redifferentiation, accumulation of senescent cells, and improper adipocytokine production. The characteristic manifestation is the increased volume of visceral adipose tissue and the reduced volume of subcutaneous adipose tissue.
