Fig. 2: The combinations of Syrosingopine and UK-5099 induced cell cycle arrest and apoptosis. | Cell Death & Disease

Fig. 2: The combinations of Syrosingopine and UK-5099 induced cell cycle arrest and apoptosis.

From: Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response

Fig. 2

A Cell cycle analysis showing the distribution of H661 and PC-9 cells in different cell cycle phases post-treatment with Syrosingopine, UK-5099, or their combination (n = 3). B Western blot detection of the level of cyclin D1 protein after treatment with Syrosingopine, UK-5099, or their combination (n = 3). C The effect of Syrosingopine and UK-5099 on the invasion capabilities of H661 and PC-9 cells was determined by Transwell invasion assays (n = 3). D The effect of Syrosingopine and UK-5099 on the migratory capabilities of H661 and PC-9 cells was determined by a scratch wound assay (n = 3). E Flow cytometric analysis of apoptosis via Annexin V-FITC/PI staining in H661 and PC-9 cells following exposure to Syrosingopine, UK-5099, or their combination (n = 3). (P-values: not significant (ns) p > 0.05, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001).

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